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Pdcd1 (NM_008798) Mouse Recombinant Protein

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SKU
TP700257
Purified recombinant protein of mouse programmed cell death 1 (PD-1 / PDCD1), with C-terminal DDK/His tag, expressed in human cells, 20 µg
Size:
20 ug
  $900.00
In Stock*
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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, MR227347, encoding the region (Leu25 – Gln167) of mouse PDCD1
Tag C-DDK/His
Predicted MW 19 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH 7.4, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_032824
Locus ID 18566
UniProt ID Q02242
Cytogenetics 1 D
RefSeq Size 1972
RefSeq ORF 867
Synonyms Ly101; PD-1; Pdc1
Summary Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:10485649, PubMed:11698646, PubMed:11209085, PubMed:21300912). Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:11015443, PubMed:11224527, PubMed:22641383, PubMed:18287011, PubMed:18641123). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:22641383). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (PubMed:11698646, PubMed:22641383). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity).UniProtKB/Swiss-Prot Function
Protein Categories ADC Targets, Allergies and autoimmune diseases, CD Markers, Intracellular Proteins, Membrane Proteins, Nervous system Diseases
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Other "Pdcd1" proteins (2)
SKU Description Size Price
TP527347 Purified recombinant protein of Mouse programmed cell death 1 (Pdcd1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug 20 ug
$1,020.00
TP700258 Purified recombinant protein of mouse programmed cell death 1 (PD-1 / PDCD1), with C-terminal Fc tag, expressed in human cells, 20 µg 20 ug
$900.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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