CD5 (NM_014207) Human Recombinant Protein

SKU
TP700241
Purified Recombinant protein of human CD5 molecule (CD5), with C-terminal DDK/His tag, expressed in human cells, 20 µg
  $900.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC206494, encoding the region (Arg25 – Asn371) of human CD5
Tag C-DDK/His
Predicted MW 41 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH 7.4, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_055022
Locus ID 921
UniProt ID P06127
Cytogenetics 11q12.2
RefSeq Size 3180
RefSeq ORF 1485
Synonyms LEU1; T1
Summary This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Oct 2016
Protein Categories CD Markers, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Hematopoietic cell lineage
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file-alt Citations

Combination of two anti-CD5 monoclonal antibodies synergistically induces complement-dependent cytotoxicity of chronic lymphocytic leukaemia cells
Klitgaard, Koefoed, Geisler et al
Br. J. Haematol. (2013)
Cited by 30
AI Summary: OriGene's human recombinant CD5 extracellular domain (ECD) protein (catalog number TC123836) was used in this study to generate and characterize monoclonal antibodies targeting CD5 for evaluating their cytotoxic effects on chronic lymphocytic leukaemia cells.
Snippet: Human recombinant CD5 extracellular domain (ECD) (TC123836, OriGene) was expressed in N-terminal fusion with human growth hormone (hGH) in human embryonic kidney (HEK) 293 cells, and CD5-ECD and hGH separated and purified as described (Leahy et al, 2000).
Showing 1-1 of 1 papers.
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