CTLA4 (NM_005214) Human Recombinant Protein

CAT#: TP700217

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Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1, with C-terminal human Fc and his tags, expressed in human cells


 Product Datasheet for 'TP700217'

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USD 748.00


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    • 20 ug


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Product Data
Description Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1, with C-terminal human Fc and his tags, expressed in human cells
Species Human
Expression Host HEK293
Tag C-Fc/His
Predicted MW 40 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Reference Data
RefSeq NP_005205
Locus ID 1493
Refseq Size 1997
Cytogenetics 2q33.2
Refseq ORF 672
Synonyms ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
Summary This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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