EGFR (NM_201283) Human Recombinant Protein

CAT#: TP700204

Purified recombinant protein of Homo sapiens epidermal growth factor receptor vIII (EGFR vIII) extracellular domain, residues Leu25-Ser378, with C-terminal DDK/His tag, expressed in HEK293 cells.

Product images

Specifications

Product Data

• Description: Purified recombinant protein of Homo sapiens epidermal growth factor receptor vIII (EGFR vIII) extracellular domain, residues Leu25-Ser378, with C-terminal DDK/His tag, expressed in HEK293 cells.
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC214877, encoding the extracellular domain (Leu25 - Ser378) of human epidermal growth factor receptor vIII (EGFR vIII)
• Tag: C-DDK/HIS
• Predicted MW: 41 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: DPBS, 10% glycerol

Reference Data

• RefSeq: NP_958440
• Locus ID: 1956
• Refseq Size: 1595
• Cytogenetics: 7p11.2
• Refseq ORF: 1215
• Synonyms: ERBB; ERBB1; HER1; mENA; NISBD2; PIG61
• Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
• Protein Families: Stem cell relevant signaling - JAK/STAT signaling pathway, Protein Kinase, Secreted Protein, ES Cell Differentiation/IPS, Transmembrane, Adult stem cells, Cancer stem cells, Druggable Genome
• Protein Pathways: MAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Dorso-ventral axis formation, Focal adhesion, Adherens junction, Gap junction, Regulation of actin cytoskeleton, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer