EGFR (NM_201283) Human Recombinant Protein

CAT#: TP700204

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Purified recombinant protein of Homo sapiens epidermal growth factor receptor vIII (EGFR vIII) extracellular domain, residues Leu25-Ser378, with C-terminal DDK/His tag, expressed in HEK293 cells.



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USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Homo sapiens epidermal growth factor receptor vIII (EGFR vIII) extracellular domain, residues Leu25-Ser378, with C-terminal DDK/His tag, expressed in HEK293 cells.
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC214877, encoding the extracellular domain (Leu25 - Ser378) of human epidermal growth factor receptor vIII (EGFR vIII)
Tag C-DDK/His
Predicted MW 41 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_958440
Locus ID 1956
Refseq Size 1595
Cytogenetics 7p11.2
Refseq ORF 1215
Synonyms ERBB; ERBB1; HER1; mENA; NISBD2; PIG61
Summary The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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EGFR mouse monoclonal antibody, clone OTI3H2 (formerly 3H2)
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