EGFR (NM_201283) Human Recombinant Protein
SKU
TP314877
Recombinant protein of human epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), transcript variant 3, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 42.4 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_958440 |
| Locus ID | 1956 |
| UniProt ID | P00533 |
| Cytogenetics | 7p11.2 |
| RefSeq Size | 1595 |
| RefSeq ORF | 1215 |
| Synonyms | ERBB; ERBB1; ERRP; HER1; mENA; NISBD2; PIG61 |
| Summary | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). provided by RefSeq, Jul 2020 |
| Protein Categories | ADC Targets, Cancer: Bladder, Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Head and Neck, Cancer: Lung, CAR-T Targets, Cytokines, Enzyme: Kinases, Growth Factors, Immune system diseases, Membrane Proteins, Secreated Proteins |
| Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane |
| Protein Pathways | Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
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| LC404515 | Lyophilized EGFR HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
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| LY404514 | Transient overexpression lysate of epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), transcript variant 2 (as WB positive control) | 100 ug |
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| LY404515 | Transient overexpression lysate of epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), transcript variant 3 (as WB positive control) | 100 ug |
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| LY417434 | Transient overexpression lysate of epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), transcript variant 1 (as WB positive control) | 100 ug |
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| TP700043 | Recombinant protein of human epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR),residues 25-645 aa, expressed in human cells | 20 ug |
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| TP700065 | Purified protein of Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mutant L858R, with C-terminal MYC/DDK tag, expressed in human cells, 20ug | 20 ug |
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| TP700080 | Purified protein of Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mutant K745_K750del, with C-terminal MYC/DDK tag, expressed in human cells, 20ug | 20 ug |
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| TP700103 | Purified recombinant protein of Human epidermal growth factor receptor (EGFR), transcript variant 3, with C-terminal DDK/His tag, expressed in human cells | 20 ug |
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| TP700204 | Purified recombinant protein of Human epidermal growth factor receptor (EGFR) extracellular domain, residues Leu25-Gly378, transcript variant 3 | 20 ug |
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| TP710003 | Recombinant protein of human epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR),residues 1-645aa,expressed in sf9 cells | 20 ug |
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| TP710011 | Recombinant protein of human epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), full length, with C-terminal DDK tag, expressed in sf9 cells | 20 ug |
$540.00
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|
| TP710358 | Purified recombinant protein of Human epidermal growth factor receptor (EGFR), transcript variant 1, esidues 669-1210aa, with C-terminal DDK tag, expressed in sf9, 20ug | 20 ug |
$540.00
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|
Citations
Bidirectional linkage of DNA barcodes for the multiplexed mapping of higher-order protein interactions in cells
Liu, Sundah, Ho et al
Nat Biomed Eng (2024)
Liu, Sundah, Ho et al
Nat Biomed Eng (2024)
Cited by 12
AI Summary: OriGene’s EGFR-DDK protein (C-terminal DDK-tagged EGFR) was used as a bait protein to facilitate the formation and analysis of two-protein complexes in the study’s DNA barcoding method for mapping protein interactions.
Snippet: for the formation of the two-protein complex anti-EGFR–EGFR-DDK, bait protein EGFR with C-terminal DDK tag (EGFR-DDK, 3 μg ml−1, OriGene) was mixed with spacer molecules (bovine serum albumin, BSA, Sigma) at 1,000-fold molar excess to allow good intercomplex distancing, and adsorbed onto either 96-well plate (MaxiSorp, Thermo Scientific) or
Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy
Sato, Ando, Okuyama et al
ACS Cent Sci (2018) 4 (11), 1559-1569 DOI: 10.1021/acscentsci.8b00565
Sato, Ando, Okuyama et al
ACS Cent Sci (2018) 4 (11), 1559-1569 DOI: 10.1021/acscentsci.8b00565
Cited by 265
AI Summary: OriGene products contributed to this study by providing the anti-EGFR monoclonal antibody (Cat# TA150117), which was conjugated with the IR700 dye to create the antibody-dye complex essential for investigating the photochemical mechanisms underlying near-infrared photoimmunotherapy-induced cancer cell cytotoxicity.
Showing 1-2 of 2 papers.
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