ATP7B (NM_000053) Human Recombinant Protein
SKU
TP323635
Recombinant protein of human ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 157.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000044 |
| Locus ID | 540 |
| UniProt ID | P35670 |
| Cytogenetics | 13q14.3 |
| RefSeq Size | 6644 |
| RefSeq ORF | 4395 |
| Synonyms | PWD; WC1; WD; WND |
| Summary | This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. provided by RefSeq, Dec 2019 |
| Protein Categories | Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "ATP7B" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH323635 | ATP7B MS Standard C13 and N15-labeled recombinant protein (NP_000044) | 10 ug |
$3,360.00
|
|
| LC424958 | Lyophilized ATP7B HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424958 | Transient overexpression lysate of ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| TP762497 | Purified recombinant protein of Human ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1, 200His-482Thr, with N-terminal His tag, expressed in E.coli, 50ug | 50 ug |
$240.00
|
|
Citations
Novel and less invasive biomarker assays to measure liver ATP7B in Wilson disease patients
Jiang, Chen, Amburgey et al
Sci Rep (2025) 15 (1), 37720 DOI: 10.1038/s41598-025-21455-y
Jiang, Chen, Amburgey et al
Sci Rep (2025) 15 (1), 37720 DOI: 10.1038/s41598-025-21455-y
AI Summary: OriGene's ATP7B recombinant protein (Cat# TP323635) was used as a standard in the electrochemiluminescence (ECL) immunoassay developed in this study to quantify ATP7B protein levels in liver biopsy samples from Wilson disease patients.
Snippet: Electrochemiluminescence (ECL) immunoassay Anti-ATP7B capture antibody (Abcam, UK, Cat# 131208), anti-ATP7B detection antibody (Novus Biologicals, USA, Cat# NB100-361) and ATP7B recombinant protein (Origene, USA, Cat# TP323635) were purchased from commercial sources. Anti-ATP7B antibody (Novus Biologicals, USA, Cat# NB100-361) was labeled with MSD SULFO-TAG at 1:20 molar ratio using an MSD SULFO
Showing 1-1 of 1 papers.
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in shipping.
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