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RASGRF2 (NM_006909) Human Recombinant Protein

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SKU
TP323580
Recombinant protein of human Ras protein-specific guanine nucleotide-releasing factor 2 (RASGRF2), 20 µg
Size:
20 ug 1 mg 100 ug
  $867.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC223580 representing NM_006909
Red=Cloning site Green=Tags(s)

MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSCRPAGMYLLEG
CSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQDGKEWMEAIHQASYADILIER
EVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIIALNKTKERMRPYQSNQEDEDPDIKKIK
KVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSK
KPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVL
ANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLE
ELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKE
GERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKGSGQVFGHLDFKIVVEPPD
AAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKT
LNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLEL
FFATSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTT
QSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSP
AADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNTERTCDKEFII
RRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIH
LKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHF
NDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK
ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIR
EIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA

TRRLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 140.6 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_008840
Locus ID 5924
UniProt ID O14827
Cytogenetics 5q14.1
RefSeq Size 4078
RefSeq ORF 3711
Synonyms GRF2; RAS-GRF2
Summary RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. provided by RefSeq, Oct 2011
Protein Categories Intracellular Proteins
Protein Pathways MAPK signaling pathway
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Other "RASGRF2" proteins (3)
SKU Description Size Price
PH323580 RASGRF2 MS Standard C13 and N15-labeled recombinant protein (NP_008840) 10 ug
$3,360.00
LC416330 Lyophilized RASGRF2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY416330 Transient overexpression lysate of Ras protein-specific guanine nucleotide-releasing factor 2 (RASGRF2) (as WB positive control) 100 ug
$665.00

file-alt Citations

The inhibition of RasGRF2, but not RasGRF1, alters cocaine reward in mice
Bernardi, Olevska, Morella et al
J. Neurosci. (2019) 39 (32), 6325-6338 DOI: 10.1523/JNEUROSCI.1120-18.2019
AI Summary: OriGene contributed shRNA expression plasmids targeting RasGRF1 and RasGRF2, which were used to knock down these genes and investigate their roles in cocaine self-administration in mice.
Snippet: Briefly, expression 142 plasmids for Ras-GRF1 and Ras-GRF2 RNA interference were obtained from a commercial 143 source (OriGene, Rockville, MD). The following sequences were used as shRNA inserts 144 against RasGRF1 and RasGRF2, respectively: 145
Showing 1-1 of 1 papers.
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