Cytochrome P450 2A6 (CYP2A6) (NM_000762) Human Recombinant Protein
SKU
TP322995
Recombinant protein of human cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6), 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 56.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000753 |
| Locus ID | 1548 |
| UniProt ID | P11509 |
| Cytogenetics | 19q13.2 |
| RefSeq Size | 1775 |
| RefSeq ORF | 1482 |
| Synonyms | CPA6; CYP2A; CYP2A3; CYPIIA6; P450C2A; P450PB |
| Summary | This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Caffeine metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Retinol metabolism |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Cytochrome P450 2A6" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH322995 | CYP2A6 MS Standard C13 and N15-labeled recombinant protein (NP_000753) | 10 ug |
$3,360.00
|
|
| LC424530 | Lyophilized CYP2A6 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424530 | Transient overexpression lysate of cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6) (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Organ-specific electrophile responsivity mapping in live C. elegans
Liu, Kulkarni, Gao et al
Cell (2024)
Liu, Kulkarni, Gao et al
Cell (2024)
Cited by 12
AI Summary: In this study, the OriGene Cytochrome P450 2A6 Human Recombinant Protein (Cat#TP322995) was used to investigate electrophile responsivity, aiding in the mapping and functional analysis of organ-specific electrophile sensing in live C. elegans.
Snippet: rypLE Express Enzyme GIBCO Cat#12605028 Cytochrome P450 2A6 Human Recombinant Protein OriGene Technologies Cat#TP322995 PEI MAX - Transfection Grade Polysciences Cat#24765-1
Organ-specific electrophile responsivity mapping in liveC. elegans
Liu, Kulkarni, Gao et al
bioRxiv (2024)
Liu, Kulkarni, Gao et al
bioRxiv (2024)
Cited by 2
Snippet: TrypLE Express Enzyme GIBCO Cat#12605028 Cytochrome P450 2A6 Human Recombinant Protein OriGene Technologies Cat#TP322995 PEI MAX - Transfection Grade Polysciences Cat#24765-1 HyCell TransFx-H transfection media Cytiva Cat#SH30939
Showing 1-2 of 2 papers.
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in shipping.
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