HTRA1 (NM_002775) Human Recombinant Protein
SKU
TP322362SE
Purified recombinant protein of Human HtrA serine peptidase 1 (HTRA1), (Secreted), 20ug
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 52.6 kDa |
| Concentration | >50 ug/mL as determined by microplate Bradford method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25mM Tris-HCl, pH7.3, 100mM glycine, 10% glycerol |
| Preparation | Conditioned medium was collected from overexpressed HEK293 cells. Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps |
| Note | For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C after receiving vials. |
| Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002766 |
| Locus ID | 5654 |
| UniProt ID | Q92743 |
| Cytogenetics | 10q26.13 |
| RefSeq Size | 2133 |
| RefSeq ORF | 1440 |
| Synonyms | ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11 |
| Summary | This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. provided by RefSeq, Jul 2008 |
| Protein Categories | Enzyme: Peptidases, Growth Factors, Intracellular Proteins, Nervous system Diseases, Secreated Proteins |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Citations
N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration
Chen, Melo, Jakob et al
Matrix Biol. (2018)
Chen, Melo, Jakob et al
Matrix Biol. (2018)
AI Summary: OriGene products, specifically the recombinant proteins HtrA1S328A (TP700208) and HtrA1WT (TP322362), were used in this study to assess HtrA1's cleavage activity and specificity toward thrombospondin-1, contributing to the identification of a proangiogenic fragment relevant to age-related macular degeneration.
Snippet: ;Specificity profiling was performed as described elsewhere [59, 72]. In brief, proteomederived peptide libraries were generated using Hek293T cell lysate digested with either trypsin or GluC [72]. Recombinant proteins of HtrA1S328A and HtrA1WT were purchased from Origene (TP700208, TP322362)
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
Melo, Oertle, Trepp et al
EBioMedicine (2017)
Melo, Oertle, Trepp et al
EBioMedicine (2017)
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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