IREB2 (NM_004136) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 104.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004127 |
| Locus ID | 3658 |
| UniProt ID | P48200 |
| Cytogenetics | 15q25.1 |
| RefSeq Size | 3928 |
| RefSeq ORF | 2889 |
| Synonyms | ACO3; IRE-BP 2; IRE-BP2; IRP2; IRP2AD; NDCAMA |
| Summary | The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Aug 2017 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "IREB2" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH321385 | IREB2 MS Standard C13 and N15-labeled recombinant protein (NP_004127) | 10 ug |
$3,360.00
|
|
| LC418191 | Lyophilized IREB2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY418191 | Transient overexpression lysate of iron-responsive element binding protein 2 (IREB2) (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2
Miyazawa, Bogdan, Tsuji
Cell Chem Biol (2018) 26 (1), 85-97.e4 DOI: 10.1016/j.chembiol.2018.10.009
Miyazawa, Bogdan, Tsuji
Cell Chem Biol (2018) 26 (1), 85-97.e4 DOI: 10.1016/j.chembiol.2018.10.009
AI Summary: OriGene’s Human Myc-Flag-tagged IRP2 protein (Cat# TP321385) was used in this study to investigate how cisplatin directly inhibits IRP2 and disrupts iron metabolism.
Snippet: Human Myc-Flag-tagged IRP2 protein Origene TP321385 [γ-32P] ATP PerkinElmer BLU002A T4 polynucleotide kinase New England Biolabs M0201
Showing 1-1 of 1 papers.
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