Integrin alpha 3 (ITGA3) (NM_005501) Human Recombinant Protein
SKU
TP320975
Recombinant protein of human integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b, 20 µg
$737.00
5 Days*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 115.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_005492 |
| Locus ID | 3675 |
| UniProt ID | P26006 |
| Cytogenetics | 17q21.33 |
| RefSeq Size | 4495 |
| RefSeq ORF | 3198 |
| Synonyms | CD49C; GAP-B3; GAPB3; ILNEB; MSK18; VCA-2; VL3A; VLA3a |
| Summary | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. provided by RefSeq, Oct 2015 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Integrin alpha 3" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH320975 | ITGA3 MS Standard C13 and N15-labeled recombinant protein (NP_005492) | 10 ug |
$3,360.00
|
|
| LC417256 | Lyophilized ITGA3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC419471 | Lyophilized ITGA3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY417256 | Transient overexpression lysate of integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b (as WB positive control) | 100 ug |
$665.00
|
|
| LY419471 | Transient overexpression lysate of integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant a (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
Saini, Mirji, Islam et al
Cancer Res (2025)
Saini, Mirji, Islam et al
Cancer Res (2025)
AI Summary: OriGene’s recombinant proteins ITGB6 (cat. #TP317387), ITGA3 (cat. #TP320975), and ITGB1 (cat. #TP303818) were used to investigate protein interactions with Siglec-10, helping to identify integrin α3β1 as a key ligand involved in immune evasion by pancreatic cancer cells.
Snippet: … The following recombinant proteins were tested: CD47 (His tag, ACRObiosystems, cat. #CD7-H5227), CD59 (His, Avitag, ACRObiosystems, cat. #CD9-H82E3), NT5E/CD73 (His, Avitag, ACRObiosystems, cat. #CD3-H82E3), ITGB6 (C-Myc/DDK, OriGene, cat. #TP317387), ITGA3 (C-Myc/DDK, OriGene, cat. #TP320975), and ITGB1 (C-Myc/DDK, OriGene, cat. #TP303818). …
An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family
Cegarra, Cameron, Chaves et al
PLoS One (2022) 17 (9), e0274667 DOI: 10.1371/journal.pone.0274667
Cegarra, Cameron, Chaves et al
PLoS One (2022) 17 (9), e0274667 DOI: 10.1371/journal.pone.0274667
Cited by 7
AI Summary: OriGene’s recombinant integrin proteins—specifically human monomer α3 (tp320975), α5 (tp301151), and β1 (tp303818)—were used as targets to identify and characterize antibodies capable of crossing the blood-brain barrier in this study.
Snippet: lonal antibodies and transcytosis in order to select the best candidate for in vivo validation. Materials and methods Proteins, reagents, cell lines Recombinant integrin proteins were purchased from OriGene for human monomer α3, α5 and β1 (tp320975, tp301151 and tp303818), from GeneTex for human monomer α4 (GTX48181), from R&D Systems for human and mouse dimer α3β1, α4β1 and α5β1 (2840
Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer
Ke, Chen, Lin et al
Cancer Sci (2020) 111 (10), 3478-3492 DOI: 10.1111/cas.14566
Ke, Chen, Lin et al
Cancer Sci (2020) 111 (10), 3478-3492 DOI: 10.1111/cas.14566
Cited by 13
AI Summary: In this study, OriGene products—including the ITGA3 cDNA clone (RC210532) and ITGA3 shRNA plasmid (TL312099)—were used to manipulate and analyze integrin α3 expression, aiding the identification and validation of integrin α3 as the target of the novel therapeutic monoclonal antibody OV-Ab 30-7 for ovarian cancer.
Showing 1-3 of 3 papers.
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