PDE5A (NM_033430) Human Recombinant Protein

CAT#: TP318974

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Recombinant protein of human phosphodiesterase 5A, cGMP-specific (PDE5A), transcript variant 2


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USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human phosphodiesterase 5A, cGMP-specific (PDE5A), transcript variant 2
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 94.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_236914
Locus ID 8654
Refseq Size 6836
Cytogenetics 4q26
Refseq ORF 2499
Synonyms CGB-PDE; CN5A; PDE5
Summary This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Progesterone-mediated oocyte maturation, Purine metabolism

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