P2X3 (P2RX3) (NM_002559) Human Recombinant Protein
SKU
TP318626
Recombinant protein of human purinergic receptor P2X, ligand-gated ion channel, 3 (P2RX3), 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 44.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002550 |
| Locus ID | 5024 |
| UniProt ID | P56373 |
| Cytogenetics | 11q12.1 |
| RefSeq Size | 1349 |
| RefSeq ORF | 1191 |
| Synonyms | P2X3 |
| Summary | This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. provided by RefSeq, Aug 2017 |
| Protein Categories | Membrane Proteins |
| Protein Families | Druggable Genome, Ion Channels: ATP Receptors, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "P2X3" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH318626 | P2RX3 MS Standard C13 and N15-labeled recombinant protein (NP_002550) | 10 ug |
$3,360.00
|
|
| LC419263 | Lyophilized P2RX3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419263 | Transient overexpression lysate of purinergic receptor P2X, ligand-gated ion channel, 3 (P2RX3) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Accurate Prediction of Core-Hopping Transformations Using Molecular Dynamics-Derived Conformational Ensembles: Application to the Discovery of Novel P2X3 Antagonists
Pala, Fiorelli, Bruno et al
J Med Chem (2026) 69 (6), 6569-6595 DOI: 10.1021/acs.jmedchem.5c02642
Pala, Fiorelli, Bruno et al
J Med Chem (2026) 69 (6), 6569-6595 DOI: 10.1021/acs.jmedchem.5c02642
Cited by 1
AI Summary: In this study, the OriGene human receptor P2X3 protein (catalog number TP318626) was used as a key reagent for fluorescent labeling and subsequent binding assays to evaluate the activity of newly designed P2X3 antagonists.
Snippet: uman receptor P2X3 (Origene, TP318626) was fluorescently labeled on lysine residues following the Monolith Protein Labeling Kit RED-NHS Second Generation protocol (NanoTemper). The protein was first diluted to a final concentration of 5 μM and buffer exchanged into NanoTemper NHS-Labeling Buffer (130 mM NaHCO3, 50 mM NaCl, pH 8.2–8.3) using Zeba Spin Desalting Columns, 7K (Thermo Fis
Showing 1-1 of 1 papers.
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