TCF4 (NM_003199) Human Recombinant Protein
SKU
TP317718L
Recombinant protein of human transcription factor 4 (TCF4), transcript variant 2, 1 mg
$7,820.00
5 Days*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 71.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_003190 |
| Locus ID | 6925 |
| UniProt ID | P15884 |
| Cytogenetics | 18q21.2 |
| RefSeq Size | 2500 |
| RefSeq ORF | 2001 |
| Synonyms | bHLHb19; CDG2T; E2-2; FECD3; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4 |
| Summary | This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. provided by RefSeq, Jul 2016 |
| Protein Categories | Intracellular Proteins, Nervous system Diseases, Secreated Proteins, Transciption Factors |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with β-catenin/TCF4 interaction in colorectal cancer cells
Li, Pu, Jiang et al
PLoS ONE (2013) 8 (7), e68525 DOI: 10.1371/journal.pone.0068525
Li, Pu, Jiang et al
PLoS ONE (2013) 8 (7), e68525 DOI: 10.1371/journal.pone.0068525
Cited by 46
AI Summary: In this study, OriGene's purified human recombinant TCF4 protein was used to investigate how henryin disrupts the interaction between β-catenin and TCF4 in colorectal cancer cells, thereby elucidating its inhibitory effect on Wnt signaling.
Snippet: Louis, MO, USA). Purified human recombinant proteins β-catenin was purchased from Sino biological inc. Purified human recombinant proteins TCF4 was purchased from OriGene. Dual-luciferase reporter gene assay system was purchased from Promega (Madison, WI, USA).
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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