FOXP3 (NM_014009) Human Recombinant Protein
$867.00
4 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 47.1 kDa |
| Concentration | >0.1 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Enzyme substrate (PMID: 30054205) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_054728 |
| Locus ID | 50943 |
| UniProt ID | Q9BZS1 |
| Cytogenetics | Xp11.23 |
| RefSeq Size | 1869 |
| RefSeq ORF | 1293 |
| Synonyms | AIID; DIETER; IPEX; JM2; PIDX; XPID |
| Summary | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Jul 2008 |
| Protein Categories | ADC Targets, Cytokines, Diabetes, Growth Factors, Immune system diseases, Intracellular Proteins, Transciption Factors |
| Protein Families | Transcription Factors |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "FOXP3" proteins (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH317580 | FOXP3 MS Standard C13 and N15-labeled recombinant protein (NP_054728) | 10 ug |
$3,360.00
|
|
| LC402270 | Lyophilized FOXP3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC426481 | Lyophilized FOXP3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY402270 | Transient overexpression lysate of forkhead box P3 (FOXP3), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| LY426481 | Transient overexpression lysate of forkhead box P3 (FOXP3), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| TP760693 | Purified recombinant protein of Human forkhead box P3 (FOXP3), transcript variant 2, (10ug), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug | 50 ug |
$270.00
|
|
Citations
PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
Stathopoulou, Gangaplara, Mallett et al
Immunity (2018) 49 (2), 247-263.e7 DOI: 10.1016/j.immuni.2018.05.006
Stathopoulou, Gangaplara, Mallett et al
Immunity (2018) 49 (2), 247-263.e7 DOI: 10.1016/j.immuni.2018.05.006
AI Summary: OriGene's Human Foxp3 protein and Tbet protein were used in cleavage assays to investigate how asparaginyl endopeptidase (AEP) affects the stability of these key regulatory proteins in T cells.
Snippet: ;Human Foxp3 protein and Tbet protein was purchased from Origene and then used in the cleavage assay in the presence of purified AEP protein (kindly provided by Dr. Colin Watts). Briefly, 1 μg of human AEP protein was incubated in 200 μL of activation buffer (0.1M NaCl, 0.1M NaOAc, pH 4.5) in 96 well round bottom plates for 30 mins at 37°C
Functional characterization of Foxp3-specific spontaneous immune responses
Larsen, Munir, Woetmann et al
Leukemia (2013)
Larsen, Munir, Woetmann et al
Leukemia (2013)
Cited by 25
AI Summary: OriGene's recombinant Foxp3 protein was used to pulse dendritic cells, enabling the study of how Foxp3-specific cytotoxic T cells recognize and respond to Foxp3-expressing cells in this research on immune regulation.
Snippet: the enzyme substrate nitro-blue tetrazolium chloride/5-bromo-4-chloro-3'-indolyphosphate p-toluidine salt (Invitrogen Life Technologies) was ... Mature autologous dendritic cells (DC) were incubated overnight with or without Foxp3 protein (20 μg) (OriGene, Rockville, MD, USA
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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