DPYD (NM_000110) Human Recombinant Protein

CAT#: TP316374

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Recombinant protein of human dihydropyrimidine dehydrogenase (DPYD)


 Product Datasheet for 'TP316374'

  View other "DPYD" proteins (3)

USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human dihydropyrimidine dehydrogenase (DPYD)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 111.2 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000101
Locus ID 1806
Refseq Size 4451
Cytogenetics 1p21.3
Refseq ORF 3075
Synonyms DHP; DHPDHASE; DPD
Summary The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Protein Families Druggable Genome
Protein Pathways beta-Alanine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Pantothenate and CoA biosynthesis, Pyrimidine metabolism

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Other Versions

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68 Mouse Clones
HUMAN PROREINS 101