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HDAC7 (NM_015401) Human Recombinant Protein

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SKU
TP315233
Recombinant protein of human histone deacetylase 7 (HDAC7), transcript variant 1, 20 µg
Size:
20 ug 1 mg 100 ug
  $867.00
4 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Recombinant protein was produced with TrueORF clone, RC215233. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 106.6 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_056216
Locus ID 51564
UniProt ID Q8WUI4
Cytogenetics 12q13.11
RefSeq Size 4301
RefSeq ORF 2973
Synonyms HD7; HD7A; HDAC7A
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008
Protein Categories Intracellular Proteins
Protein Families Druggable Genome, Transcription Factors
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Documents
Resources
Other "HDAC7" proteins (1)
SKU Description Size Price
PH315233 HDAC7 MS Standard C13 and N15-labeled recombinant protein (NP_056216) 10 ug
$3,360.00

file-alt Citations

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling
Hsu, Duan, McMahon et al
J. Clin. Invest. (2020)
AI Summary: OriGene’s recombinant HDAC7 protein was used in kinase assays to investigate the phosphorylation and stabilization of HDAC7 by SIK1, elucidating their role in pathologic cardiac remodeling.
Snippet: 10ng of recombinant SIK1 (Thermo Fisher) and 100ng of recombinant HDAC7 (Origene) were 545 incubated in a final volume of 40uL containing 1X kinase buffer (CST) supplemented with 100uM 546 ATP. 1uM of YKL-05-099 was added for inhibition of SIK1 activity. Reactions were incubated for
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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