ROR1 (NM_005012) Human Recombinant Protein

CAT#: TP314967

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Recombinant protein of human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1


 Product Datasheet for 'TP314967'

 Cited in 1 publication.

  View other "ROR1" proteins (10)

USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC214967. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 104.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity ELISA capture for autoantibodies (PMID: 26562161)
WB positive control (PMID: 26562161)
Affinity purification chromatography (PMID: 26562161)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_005003
Locus ID 4919
Refseq Size 3358
Cytogenetics 1p31.3
Refseq ORF 2811
Synonyms dJ537F10.1; NTRKR1
Summary This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Protein Families Druggable Genome, Protein Kinase, Transmembrane

Citations (1)

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