CBL (NM_005188) Human Recombinant Protein
SKU
TP314069
Recombinant protein of human Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL), 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 99.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_005179 |
| Locus ID | 867 |
| UniProt ID | P22681 |
| Cytogenetics | 11q23.3 |
| RefSeq Size | 11242 |
| RefSeq ORF | 2718 |
| Synonyms | C-CBL; CBL2; FRA11B; NSLL; RNF55 |
| Summary | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. provided by RefSeq, Jul 2016 |
| Protein Categories | Cancer: Haematopoietic and Lymphoid, Cytokines, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CBL" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH314069 | CBL MS Standard C13 and N15-labeled recombinant protein (NP_005179) | 10 ug |
$3,360.00
|
|
| LC401588 | Lyophilized CBL HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401588 | Transient overexpression lysate of Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) (as WB positive control) | 100 ug |
$665.00
|
|
Citations
SDCBP competes with CBL to stabilize PES1 and promote c-Myc translation in ESCC tumorigenesis
Xiao, Luo, Du et al
Cell Rep (2026) 45 (10), 118013 DOI: 10.1016/j.celrep.2026.118013
Xiao, Luo, Du et al
Cell Rep (2026) 45 (10), 118013 DOI: 10.1016/j.celrep.2026.118013
Antagonistic SUMOylation and Ubiquitination of ACSL4 Control Ferroptosis in Colorectal Cancer
Luo, Zhang, Feng1 et al
Research Square (2026)
Luo, Zhang, Feng1 et al
Research Square (2026)
AI Summary: OriGene’s recombinant CBL protein (TP314069) was used in in vitro binding assays to investigate protein interactions relevant to the regulation of ferroptosis in colorectal cancer.
Snippet: uorescence microscope (Zeiss) to assess colocalization. Images were processed using ImageJ software. IN VITRO BINDING ASSAYS Recombinant human ACSL4 (ABIN7232834, antibodies-online), CBL (TP314069, OriGene), and PIAS1 (H00008554-P01, Abnova) proteins were used for in vitro binding assays. Purified His-tagged ACSL4 was incubated with GST or GST-PIAS1, followed by rotation with anti-GST magnetic b
Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex
Gregor, Bosakova, Nita et al
Cell. Mol. Life Sci. (2019)
Gregor, Bosakova, Nita et al
Cell. Mol. Life Sci. (2019)
Cited by 18
Showing 1-3 of 3 papers.
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