STAT1 (NM_007315) Human Recombinant Protein
SKU
TP313858
Recombinant protein of human signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant alpha, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 87.2 kDa |
| Concentration | >0.2 mg/mL as determined by microplate BCA method |
| Purity | >90% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 50 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Enzyme substrate (PMID: 27796300) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_009330 |
| Locus ID | 6772 |
| UniProt ID | P42224 |
| Cytogenetics | 2q32.2 |
| RefSeq Size | 4157 |
| RefSeq ORF | 2250 |
| Synonyms | CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91 |
| Summary | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. provided by RefSeq, Jun 2020 |
| Protein Categories | Chemokines, Cytokines, Growth Factors, Immune system diseases, Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer, Toll-like receptor signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "STAT1" proteins (10)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301075 | STAT1 MS Standard C13 and N15-labeled recombinant protein (NP_644671) | 10 ug |
$3,360.00
|
|
| PH313858 | STAT1 MS Standard C13 and N15-labeled recombinant protein (NP_009330) | 10 ug |
$3,360.00
|
|
| LC408329 | Lyophilized STAT1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC416045 | Lyophilized STAT1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC429341 | Lyophilized STAT1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY408329 | Transient overexpression lysate of signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta (as WB positive control) | 100 ug |
$436.00
|
|
| LY416045 | Transient overexpression lysate of signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant alpha (as WB positive control) | 100 ug |
$665.00
|
|
| LY429341 | Transient overexpression lysate of signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant alpha (as WB positive control) | 100 ug |
$665.00
|
|
| TP301075 | Recombinant protein of human signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta, 20 µg | 20 ug |
$867.00
|
|
| TP720884 | Purified recombinant protein of Human signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta | 10 ug |
$275.00
|
|
Citations
WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage
Han, Wen, García-Rubio et al
Nat Commun (2022) 13 (1), 3743 DOI: 10.1038/s41467-022-31415-z
Han, Wen, García-Rubio et al
Nat Commun (2022) 13 (1), 3743 DOI: 10.1038/s41467-022-31415-z
Cited by 37
AI Summary: OriGene products, specifically RPA1 (TP302066), RPA2 (TP305715), MAX (TP320343), ARP3 (TP308460), FANCA (TP761743), XRCC2 (TP308330), DNMT1 (TP326414), MYC (TP301611), NF-κB1 (TP308384), and STAT1 (TP313858), were used as key reagents to investigate the molecular mechanisms by which WASp modulates RPA function and maintains genomic stability under replication stress and DNA damage.
Snippet: ns RPA1 (TP302066), RPA2 (TP305715), MAX (TP320343), ARP3 (TP308460), FANCA (TP761743), XRCC2 (TP308330), DNMT1 (TP326414), MYC (TP301611), NF-κB1 (TP308384) and STAT1 (TP313858) were purchased from OriGene (Rockville, MD). ARP2 (ab217837) was purchased from Abcam (Cambridge, MA). Heterotrimeric RPA and RPA1 mutant forms of RPA were expressed as recombinant protein E. coli and them purified over
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
Iwata, Goettsch, Sharma et al
Nat Commun (2016) 7, 12849 DOI: 10.1038/ncomms12849
Iwata, Goettsch, Sharma et al
Nat Commun (2016) 7, 12849 DOI: 10.1038/ncomms12849
Cited by 310
AI Summary: In this study, the recombinant human STAT1α protein from OriGene Technologies was used in ADP-ribosylation assays to investigate how PARP9 and PARP14 regulate macrophage activation through STAT1 modification.
Snippet: … ADP-ribosylation assays Recombinant human PARP14 and PARP9 (BPS Bioscience Inc.) proteins and BSA (Sigma-Aldrich) were incubated with recombinant human STAT1α (OriGene Technologies Inc.) or STAT6 protein (Sino Biological Inc.) at a final concentration of 5 ng μl−1 in the presence of 100 μM β-nicotinamide adenine dinucleotide hydrate (NAD;Sigma-Al;Recombinant human PARP14 and PARP9 (BPS Bioscience Inc.) proteins and BSA (Sigma-Aldrich) were incubated with recombinant human STAT1α (OriGene Technologies Inc.) or STAT6 protein (Sino Biological Inc.) at a final concentration of 5 ng μl−1 in the presence of 100 μM β-nicotinamide adenine dinucleotide hydrate (NAD;Sigma-Aldrich) or 6-biotin-17-NAD (Trevigen Inc.) in 50 mM Tris-HCl buffer (pH 7.4) for 1 h at room temperature
Showing 1-2 of 2 papers.
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