COMP (NM_000095) Human Recombinant Protein

CAT#: TP311080

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Recombinant protein of human cartilage oligomeric matrix protein (COMP)


 Product Datasheet for 'TP311080'

  View other "COMP" proteins (3)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human cartilage oligomeric matrix protein (COMP)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 80.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000086
Locus ID 1311
Refseq Size 2471
Cytogenetics 19p13.11
Refseq ORF 2271
Synonyms EDM1; EPD1; MED; PSACH; THBS5; TSP5
Summary The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways ECM-receptor interaction, Focal adhesion, TGF-beta signaling pathway

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Other Versions

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Clone OTI4C5, Anti-DDK (FLAG) monoclonal antibody
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