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PITRM1 (NM_014889) Human Recombinant Protein

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SKU
TP310596
Recombinant protein of human pitrilysin metallopeptidase 1 (PITRM1), 20 µg
Size:
20 ug 1 mg 100 ug
  $737.00
4 Weeks*
Bulk/Customize

Frequently Bought Together (2)

TA379966 PITRM1 Rabbit polyclonal Antibody
100 ul
$410.00
TA592569 DDK Rabbit monoclonal antibody, recognizing both N- and C-terminal tags
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC210596 protein sequence
Red=Cloning site Green=Tags(s)

MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHD
DTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTA
SDYTVYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAF
TDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQI
HEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTVSVSFLLPDITDTFEAFTLSLLS
SLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIVEKDIETVRSLIDRTIDEVVEKGF
EDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVK
QYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPAL
KVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLL
DYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFK
VLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKK
HLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIR
KLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASFEILARLMTAKFLHTEIREKGGAYGGGA
KLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYG
LSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIR

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 117.2 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_055704
Locus ID 10531
UniProt ID Q5JRX3
Cytogenetics 10p15.2
RefSeq Size 3505
RefSeq ORF 3111
Synonyms MP1; PreP
Summary The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. provided by RefSeq, Dec 2016
Protein Categories Enzyme: Peptidases, Intracellular Proteins, Nervous system: Neurodegenerative diseases
Protein Families Druggable Genome, Protease
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Other "PITRM1" proteins (3)
SKU Description Size Price
PH310596 PITRM1 MS Standard C13 and N15-labeled recombinant protein (NP_055704) 10 ug
$3,360.00
LC414960 Lyophilized PITRM1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY414960 Transient overexpression lysate of pitrilysin metallopeptidase 1 (PITRM1) (as WB positive control) 100 ug
$436.00

file-alt Citations

Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis
Zhou, Wei, Deng et al
Nat Cell Biol (2023)
Cited by 63
AI Summary: In this study, OriGene's PITRM1 protein (catalog number TP310596) was used to investigate the mitochondrial processing of proteins involved in the delivery of LDL-derived cholesterol for steroidogenesis.
Snippet: Forskolin (HY-15371), LDLR protein (HY-P70235) and HTRA2 protein (HY-P4876) were from MCE. PITRM1 protein (TP310596) was from OriGene. PMPCB protein (PMPCB-2146H) was from Creative BioMart
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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