Cathepsin B (CTSB) (NM_147783) Human Recombinant Protein

CAT#: TP310578

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Recombinant protein of human cathepsin B (CTSB), transcript variant 5


 Product Datasheet for 'TP310578'

  View other "CTSB" proteins (25)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human cathepsin B (CTSB), transcript variant 5
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC210578. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 35.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_680093
Locus ID 1508
Refseq Size 3857
Cytogenetics 8p23.1
Refseq ORF 1017
Synonyms APPS; CPSB
Summary This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Protein Families Druggable Genome, Protease
Protein Pathways Antigen processing and presentation, Lysosome

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Other Versions

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BOGO Free lysates
68 Mouse Clones
HUMAN PROREINS 101