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ERK2 (MAPK1) (NM_002745) Human Recombinant Protein

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SKU
TP310493
Recombinant protein of human mitogen-activated protein kinase 1 (MAPK1), transcript variant 1, 20 µg
Size:
20 ug 1 mg 100 ug
  $867.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Recombinant protein was produced with TrueORF clone, RC210493. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 41.2 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002736
Locus ID 5594
UniProt ID P28482
Cytogenetics 22q11.22
RefSeq Size 5916
RefSeq ORF 1080
Synonyms ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2
Summary This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. provided by RefSeq, Jan 2014
Protein Categories Enzyme: Kinases, Growth Factors, Intracellular Proteins
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Acute myeloid leukemia, Adherens junction, Alzheimer's disease, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Non-small cell lung cancer, Oocyte meiosis, Pancreatic cancer, Pathways in cancer, Prion diseases, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, TGF-beta signaling pathway, Thyroid cancer, Toll-like receptor signaling pathway, Type II diabetes mellitus, Vascular smooth muscle contraction, VEGF signaling pathway
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Other "ERK2" proteins (8)
SKU Description Size Price
PH304703 MAPK1 MS Standard C13 and N15-labeled recombinant protein (NP_620407) 10 ug
$3,360.00
PH310493 MAPK1 MS Standard C13 and N15-labeled recombinant protein (NP_002736) 10 ug
$3,360.00
LC408481 Lyophilized MAPK1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC419132 Lyophilized MAPK1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY408481 Transient overexpression lysate of mitogen-activated protein kinase 1 (MAPK1), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY419132 Transient overexpression lysate of mitogen-activated protein kinase 1 (MAPK1), transcript variant 1 (as WB positive control) 100 ug
$436.00
TP304703 Recombinant protein of human mitogen-activated protein kinase 1 (MAPK1), transcript variant 2, 20 µg 20 ug
$867.00
TP750214 Purified recombinant protein of Human Mitogen-activated protein kinase 1, full length(105Gly), with N-terminal fusion Myc-FLAG tag, expressed in E.coli, 50ug 50 ug
$240.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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