alpha 5 Defensin (DEFA5) (NM_021010) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 8.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_066290 |
| Locus ID | 1670 |
| UniProt ID | Q01523 |
| Cytogenetics | 8p23.1 |
| RefSeq Size | 468 |
| RefSeq ORF | 282 |
| Synonyms | DEF5; HD-5 |
| Summary | Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. provided by RefSeq, Oct 2014 |
| Protein Categories | Secreated Proteins |
| Protein Families | Secreted Protein |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "alpha 5 Defensin" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH310219 | DEFA5 MS Standard C13 and N15-labeled recombinant protein (NP_066290) | 10 ug |
$3,360.00
|
|
| LC412137 | Lyophilized DEFA5 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY412137 | Transient overexpression lysate of defensin, alpha 5, Paneth cell-specific (DEFA5) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease
Rana, Korolkova, Rachakonda et al
PLoS One (2021) 16 (3), e0246393 DOI: 10.1371/journal.pone.0246393
Rana, Korolkova, Rachakonda et al
PLoS One (2021) 16 (3), e0246393 DOI: 10.1371/journal.pone.0246393
Cited by 16
AI Summary: OriGene’s Recombinant Human Defensin, Alpha (DEFA5) protein (TP310219) was used to treat human colonic epithelial cells and colonoids, enabling the study of DEFA5’s effects on cellular signatures and differentiation relevant to Crohn’s colitis pathogenesis.
Snippet: Invitrogen 16000036 3 PBS Invitrogen 10010023 4 Human Cytokine Membrane Antibody Array Abcam Ab133998 5 Recombinant Human Defensin, Alpha (DEFA5) 5 20ug Origene TP310219 6 IL-6 Biolegend 430508 7 TFN-α Biolegend 430201 8 DMEM-F12 Invitrogen 11320033 9 Lipopolysaccharide (LPS) Millipore Sigma
Showing 1-1 of 1 papers.
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