Cytokeratin 8 (KRT8) (NM_002273) Human Recombinant Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 53.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002264 |
| Locus ID | 3856 |
| UniProt ID | P05787 |
| Cytogenetics | 12q13.13 |
| RefSeq Size | 1788 |
| RefSeq ORF | 1449 |
| Synonyms | CARD2; CK-8; CK8; CYK8; K2C8; K8; KO |
| Summary | This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Jan 2012 |
| Protein Categories | ADC Targets, Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Cytokeratin 8" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH309570 | KRT8 MS Standard C13 and N15-labeled recombinant protein (NP_002264) | 10 ug |
$3,360.00
|
|
| LC419425 | Lyophilized KRT8 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419425 | Transient overexpression lysate of keratin 8 (KRT8) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients
Stanton, Gad, Ramos et al
NPJ Breast Cancer (2021) 7 (1), 50 DOI: 10.1038/s41523-021-00257-1
Stanton, Gad, Ramos et al
NPJ Breast Cancer (2021) 7 (1), 50 DOI: 10.1038/s41523-021-00257-1
Cited by 12
AI Summary: OriGene products, specifically the human VPS35 (Cat# RC222447), ARPC2 (Cat# RC202766), SERBP1 (Cat# RC202062), KRT8 (Cat# RC200181), and PDIA6 (Cat# RC200853) Myc-DDK-tagged ORF cDNA clones, were used to express and study the candidate tumor antigens whose autoantibody responses were analyzed in both mouse models and human breast cancer patient serum.
Showing 1-1 of 1 papers.
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