MTHFR (NM_005957) Human Recombinant Protein

CAT#: TP308588

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Recombinant protein of human 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR)


Product Datasheet for 'TP308588'


  View other "MTHFR" proteins (3)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 74.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_005948
Locus ID 4524
Refseq Size 6099
Cytogenetics 1p36.22
Refseq ORF 1968
Synonyms 5,10-methylenetetrahydrofolate reductase (NADPH); methylenetetrahydrofolate reductase intermediate form; OTTHUMP00000002367; OTTHUMP00000002368
Summary The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. [provided by RefSeq, Oct 2009]
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Methane metabolism, One carbon pool by folate

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