GCLC (NM_001498) Human Recombinant Protein

CAT#: TP307915

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Recombinant protein of human glutamate-cysteine ligase, catalytic subunit (GCLC)


Product Datasheet for 'TP307915'


  View other "GCLC" proteins (5)

USD 748.00


Availability*
4 Weeks

Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human glutamate-cysteine ligase, catalytic subunit (GCLC)
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC207915. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 72.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_001489
Locus ID 2729
Refseq Size 3823
Cytogenetics 6p12.1
Refseq ORF 1911
Synonyms GCL; GCS; GLCL; GLCLC
Summary Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. [provided by RefSeq, Oct 2010]
Protein Families Druggable Genome
Protein Pathways Glutathione metabolism, Metabolic pathways

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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