CYLD (NM_001042355) Human Recombinant Protein
SKU
TP304099
Recombinant protein of human cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 2, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 106.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001035814 |
| Locus ID | 1540 |
| UniProt ID | Q9NQC7 |
| Cytogenetics | 16q12.1 |
| RefSeq Size | 8584 |
| RefSeq ORF | 2859 |
| Synonyms | BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8; MFT; MFT1; SBS; TEM; USPL2 |
| Summary | This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. provided by RefSeq, Jul 2008 |
| Protein Categories | Enzyme: Peptidases, Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome |
| Protein Pathways | RIG-I-like receptor signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CYLD" proteins (9)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH304099 | CYLD MS Standard C13 and N15-labeled recombinant protein (NP_001035814) | 10 ug |
$3,360.00
|
|
| PH314451 | CYLD MS Standard C13 and N15-labeled recombinant protein (NP_001035877) | 10 ug |
$3,360.00
|
|
| PH319629 | CYLD MS Standard C13 and N15-labeled recombinant protein (NP_056062) | 10 ug |
$3,360.00
|
|
| LC420845 | Lyophilized CYLD HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC420886 | Lyophilized CYLD HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY420845 | Transient overexpression lysate of cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY420886 | Transient overexpression lysate of cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 3 (as WB positive control) | 100 ug |
$665.00
|
|
| TP314451 | Recombinant protein of human cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 3, 20 µg | 20 ug |
$737.00
|
|
| TP319629 | Recombinant protein of human cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 1, 20 µg | 20 ug |
$737.00
|
|
Citations
CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury
Wu, Su, Cheng et al
Cell Mol Life Sci (2025) 82 (1), 124 DOI: 10.1007/s00018-025-05654-4
Wu, Su, Cheng et al
Cell Mol Life Sci (2025) 82 (1), 124 DOI: 10.1007/s00018-025-05654-4
Cited by 7
AI Summary: OriGene’s recombinant human CYLD protein (TP304099) was used in this study to investigate the role of CYLD in regulating the TRAF6/sNASP axis and TLR4 signaling during sepsis-induced acute lung injury.
Snippet: Sigma-Aldrich), Flag (F1804, Sigma-Aldrich), and recombinant human CYLD protein (TP304099, Origene, Rockville, MD, USA). Antibody dilutions were according to the manufacturer’s
IKK regulates the deubiquitinase CYLD at the postsynaptic density
Thein, Pham, Bayer et al
Biochem. Biophys. Res. Commun. (2014)
Thein, Pham, Bayer et al
Biochem. Biophys. Res. Commun. (2014)
Cited by 28
AI Summary: OriGene Technologies contributed purified recombinant human CYLD transcript variant 2, which was used to investigate the phosphorylation and activation of CYLD in the study.
Snippet: Tetrameric K63-linked polyubiquitins are from LifeSensors (Malvern, PA). Purified recombinant human CYLD transcript variant 2 is from OriGene Technologies (Rockville, MD), and purified IKKβ is from Life technologies (Carlsbad, CA). ... Cite SaveSaving
CaMKII Mediates Recruitment and Activation of the Deubiquitinase CYLD at the Postsynaptic Density
Thein, Tao-Cheng, Li et al
PLoS ONE (2014) 9 (3), e91312 DOI: 10.1371/journal.pone.0091312
Thein, Tao-Cheng, Li et al
PLoS ONE (2014) 9 (3), e91312 DOI: 10.1371/journal.pone.0091312
Cited by 38
AI Summary: In this study, purified recombinant human CYLD transcript variant 2 from OriGene Technologies was used to investigate how CaMKII phosphorylates and activates CYLD, elucidating its role in regulating protein degradation at the postsynaptic density.
Snippet: CYLD lysate (lysate from HEKT 293 cells overexpressing human CYLD transcript variant 2) is from Novus Biologicals (Littleton, CO). Purified recombinant human CYLD transcript variant 2 is from OriGene Technologies (Rockville, MD). ... Cite SaveSaving
Showing 1-3 of 3 papers.
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