SFTPC (NM_003018) Human Recombinant Protein
$7,820.00
6 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 20.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_003009 |
| Locus ID | 6440 |
| UniProt ID | P11686 |
| Cytogenetics | 8p21.3 |
| RefSeq Size | 989 |
| RefSeq ORF | 591 |
| Synonyms | BRICD6; PSP-C; SFTP2; SMDP2; SP-C; SP5 |
| Summary | This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.provided by RefSeq, Feb 2010 |
| Protein Categories | Intracellular Proteins, Secreated Proteins |
| Protein Families | Secreted Protein, Transmembrane |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19
Sinnberg, Lichtensteiger, Hasan Ali et al
Am J Respir Crit Care Med (2022)
Sinnberg, Lichtensteiger, Hasan Ali et al
Am J Respir Crit Care Med (2022)
Cited by 1
AI Summary: OriGene’s recombinant pulmonary surfactant-associated protein B (Cat. No. TP324088) and protein C (Cat. No. TP303246) were used as antigens in ELISA assays to detect IgA autoantibodies in patient samples, helping demonstrate that these autoantibodies target and inhibit lung surfactant proteins in severe COVID-19.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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