IMPDH2 (NM_000884) Human Recombinant Protein

CAT#: TP302977

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Recombinant protein of human IMP (inosine monophosphate) dehydrogenase 2 (IMPDH2)


 Product Datasheet for 'TP302977'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human IMP (inosine monophosphate) dehydrogenase 2 (IMPDH2)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 55.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000875
Locus ID 3615
Refseq Size 1712
Cytogenetics 3p21.31
Refseq ORF 1542
Synonyms IMPD2; IMPDH-II
Summary This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

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