BAG3 (NM_004281) Human Recombinant Protein

CAT#: TP302860

Purified recombinant protein of Homo sapiens BCL2-associated athanogene 3 (BAG3)

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 Product Datasheet for 'TP302860'

USD 680.00


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Size
    • 20 ug

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Specifications

Product Data
Description Purified recombinant protein of Homo sapiens BCL2-associated athanogene 3 (BAG3)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC202860. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-MYC/DDK
Predicted MW 61.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Reference Data
RefSeq NP_004272
Locus ID 9531
Refseq Size 2608
Cytogenetics 10q26.11
Refseq ORF 1725
Synonyms BAG-3; BIS; CAIR-1; MFM6
Summary BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].
Protein Families
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