PDK4 (NM_002612) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 46.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002603 |
| Locus ID | 5166 |
| UniProt ID | Q16654 |
| Cytogenetics | 7q21.3 |
| RefSeq Size | 3710 |
| RefSeq ORF | 1233 |
| Summary | This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. provided by RefSeq, Jul 2008 |
| Protein Categories | Enzyme: Kinases, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "PDK4" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301656 | PDK4 MS Standard C13 and N15-labeled recombinant protein (NP_002603) | 10 ug |
$3,360.00
|
|
| LC400924 | Lyophilized PDK4 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400924 | Transient overexpression lysate of pyruvate dehydrogenase kinase, isozyme 4 (PDK4) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Functional Consequences of PDK4 Deficiency in Doberman Pinscher Fibroblasts
Bolfer, Estrada, Larkin et al
Sci Rep (2020) 10 (1), 3930 DOI: 10.1038/s41598-020-60879-6
Bolfer, Estrada, Larkin et al
Sci Rep (2020) 10 (1), 3930 DOI: 10.1038/s41598-020-60879-6
Cited by 13
AI Summary: OriGene’s human recombinant PDK4 protein (OriGene-TP301656) was used in functional assays to assess the impact of PDK4 deficiency in Doberman Pinscher fibroblasts in this study.
Snippet: … The measurements were acquired following steps: (1) Without substrate addition (Baseline), (2) With subsequent addition of human recombinant PDK4 (OriGene-TP301656), and (3) With subsequent addition of glutamate. PDK4 level Relative PDK4 expression levels were measured with a PDK4 ELISA kit per manufacturer’s instructions (Abcam, #ab126582).;- The measurements were acquired following steps: (1) Without substrate addition (Baseline), (2) With subsequent addition of human recombinant PDK4 (OriGene-TP301656), and (3) With subsequent addition of glutamate. PDK4 level
Showing 1-1 of 1 papers.
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