TRIB2 (NM_021643) Human Recombinant Protein
SKU
TP301210
Recombinant protein of human tribbles homolog 2 (Drosophila) (TRIB2), transcript variant 1, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 38.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_067675 |
| Locus ID | 28951 |
| UniProt ID | Q92519 |
| Cytogenetics | 2p24.3 |
| RefSeq Size | 4408 |
| RefSeq ORF | 1029 |
| Synonyms | C5FW; GS3955; TRB2 |
| Summary | This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Mar 2009 |
| Protein Categories | Enzyme: Kinases, Membrane Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "TRIB2" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301210 | TRIB2 MS Standard C13 and N15-labeled recombinant protein (NP_067675) | 10 ug |
$3,360.00
|
|
| LC402872 | Lyophilized TRIB2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY402872 | Transient overexpression lysate of tribbles homolog 2 (Drosophila) (TRIB2), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession
Liu, Song, Liang et al
Cell Death Discov (2022) 8 (1), 306 DOI: 10.1038/s41420-022-01095-1
Liu, Song, Liang et al
Cell Death Discov (2022) 8 (1), 306 DOI: 10.1038/s41420-022-01095-1
Cited by 24
AI Summary: In this study, OriGene products including TRIB2 overexpression plasmids (Cat# RC210307) and TRIB2 shRNA plasmids (Cat# TL312307) were used to manipulate TRIB2 expression, enabling the authors to demonstrate TRIB2’s role in phosphorylating PKM2 and promoting aerobic glycolysis in lung cancer cells.
Snippet: an be divided into 3 parts: an N-terminal domain (PEST), a C-terminal E3 ligase-binding domain, and a pseudokinase domain with a Ser/Thr protein kinase-like domain [21]. Owing to its importance in tumorigenesis and therapeutic resistance, targeting TRIB2 may present an exciting opportunity for cancer therapy and anti-cancer drug design. To date, the detailed roles of TRIB2 in cancer and the functi
Showing 1-1 of 1 papers.
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