Ezrin (EZR) (NM_003379) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 69.2 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | ELISA capture for autoantibodies (PMID: 27146838) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_003370 |
| Locus ID | 7430 |
| UniProt ID | P15311 |
| Cytogenetics | 6q25.3 |
| RefSeq Size | 3172 |
| RefSeq ORF | 1758 |
| Synonyms | CVIL; CVL; HEL-S-105; VIL2 |
| Summary | The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Ezrin" proteins (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH300404 | EZR MS Standard C13 and N15-labeled recombinant protein (NP_003370) | 10 ug |
$3,360.00
|
|
| PH325989 | EZR MS Standard C13 and N15-labeled recombinant protein (NP_001104547) | 10 ug |
$3,360.00
|
|
| LC401164 | Lyophilized EZR HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC426350 | Lyophilized EZR HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401164 | Transient overexpression lysate of ezrin (EZR), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| LY426350 | Transient overexpression lysate of ezrin (EZR), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| TP325989 | Recombinant protein of human ezrin (EZR), transcript variant 2, 20 µg | 20 ug |
$867.00
|
|
Citations
A prospective study of autoantibodies to Ezrin and pancreatic cancer risk
Sun, Wu, Cai et al
Cancer Causes Control (2016) 27 (6), 831-5 DOI: 10.1007/s10552-016-0757-y
Sun, Wu, Cai et al
Cancer Causes Control (2016) 27 (6), 831-5 DOI: 10.1007/s10552-016-0757-y
Cited by 5
AI Summary: OriGene’s recombinant Homo sapiens Ezrin protein (transcript variant 1) was used to coat ELISA plates for detecting anti-Ezrin autoantibodies in plasma samples, enabling assessment of their potential as biomarkers for pancreatic cancer risk in this study.
Snippet: Capello et al. [5]. Briefly, 100 μl of 1:200 diluted plasma samples was incubated in microtitration wells pre-coated with the recombinant protein of Homo sapiens Ezrin, transcript variant 1 (OriGene Technologies). After washing, HRP ... Cite SaveSaving
Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?
Miyaji, Shahrizaila, Umapathi et al
Hum. Immunol. (2014)
Miyaji, Shahrizaila, Umapathi et al
Hum. Immunol. (2014)
Cited by 12
AI Summary: OriGene’s purified recombinant human ezrin, radixin, and moesin proteins were used as antigens in ELISA assays to test for autoantibodies in patient samples, helping determine that these ERM proteins are unlikely targets in demyelinating neuropathies.
Snippet: each hospital local ethics approval. 2.2. ELISA. Purified recombinant ERM proteins of Homo sapiens, produced in HEK293 cells, were purchased from OriGene Technologies, Inc. (Rockville, MD, USA). The wells of microplates ... Cite SaveSaving
Showing 1-2 of 2 papers.
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