CLEC4E (NM_014358) Human Recombinant Protein
$2,508.00
4 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 24.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_055173 |
| Locus ID | 26253 |
| UniProt ID | Q9ULY5 |
| Cytogenetics | 12p13.31 |
| RefSeq Size | 2158 |
| RefSeq ORF | 657 |
| Synonyms | CLECSF9; MINCLE |
| Summary | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. provided by RefSeq, Jul 2008 |
| Protein Categories | Cytokines, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity
Wevers, Kaptein, Zijlstra-Willems et al
Cell Host Microbe (2014) 15 (4), 494-505 DOI: 10.1016/j.chom.2014.03.008
Wevers, Kaptein, Zijlstra-Willems et al
Cell Host Microbe (2014) 15 (4), 494-505 DOI: 10.1016/j.chom.2014.03.008
Cited by 156
AI Summary: OriGene’s DDK-tagged mincle protein (TP300244) and anti-DDK antibody (TA50011-100) were used to detect and analyze the binding of mincle to fungal conidia, helping to demonstrate how fungal engagement of mincle suppresses antifungal immune responses in the study.
Snippet: Recombinant human His-tagged dectin-1 (1859-DC-50;R&D Systems) and DDK-tagged mincle (TP300244;Origene) were incubated with heat-killed fungal conidia and subsequently labeled with anti-His (sc-8036;Santa Cruz) or anti-DDK (TA50011-100;Origene), respectively, followed by incubation with Alexa Fluor 488-conjugated anti-mouse (A11029;Invitrogen). CLR-fungi binding was analyzed on a FACS Calibur (BD)
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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