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Collagen type IV Human Protein

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SKU
RA007
Human Collagen Type IV
Size:
500 ug
  $935.00
5 Days*
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Other products for "Collagen IV or NM_001303110"

Specifications
Specifications
Product Data
Species Human
Protein Source Placenta
Concentration 1.0 mg/ml by nanodrop at 205 nm
Purity This product has been prepared from human placenta and is chromatographically and immunologically pure.  This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins.  This product reacts with anti-Collagen Type IV.  Reaction with Rockland’s anti-Collagen I, II, III, V or VI is negligible.
Buffer 0.5 M Acetic Acid
Preparation Liquid (sterile filtered) purified protein
Recommended Dilution ELISA,Immunohistochemistry,Western Blot
Protein Description This antigen is free from other Collagens, Human serum proteins and non-Collagen extracellular matrix proteins and reacts with anti-Collagen Type IV.
Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
Note Collagen type IV has been tested in SDS-Page and can be used as a control or standard in indirect trapping ELISA for quantitation of antigen using a standard curve, for immunoprecipitation and for other immunological assays as optimized by the user. Specific conditions should be optimized by user.
Storage Store vial at 4° C prior to opening. This product is stable at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Stability Expiration date is six (6) months from date of receipt.
Shipping Blue Ice
Reference Data
RefSeq NP_001290039
Locus ID 1282
Cytogenetics 13q34
Synonyms Type IV collagen, collagen 4, human collagen, Collagen alpha-4 (IV) chain
Summary This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. provided by RefSeq, Dec 2014
Protein Categories Cardiovascular diseases, Growth Factors, Intracellular Proteins, Secreated Proteins
Protein Families ELISA.
Suitable for use as a Control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve.
Immunoprecipitation.
Western blotting.
Protein Pathways ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer
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Documents
Resources

file-alt Citations

Monitoring the Remodeling of Biohybrid Tissue-Engineered Vascular Grafts by Multimodal Molecular Imaging
Rama, Mohapatra, Melcher et al
Adv Sci (Weinh) (2022) 9 (10), e2105783 DOI: 10.1002/advs.202105783
Cited by 25
AI Summary: Based on the provided abstract and snippet, there is **no mention of any OriGene products** in the referenced paper, and therefore OriGene products did not contribute to this study.
Snippet: ‐human alpha‐smooth muscle actin (_α_‐SMA) (Sigma‐Aldrich, Darmstadt, Germany);monoclonal, anti‐human CD31 (Sigma‐Aldrich, Darmstadt, Germany);polyclonal, anti‐human type I collagen (Acris Antibodies GmbH, Herford, Germany);polyclonal, anti‐human type IV collagen (Acris Antibodies GmbH, Herford, Germany);polyclonal, anti‐human elastin (Acris Antibodies GmbH, Herford, Germany;- Tissue‐engineered va...
CONTRIBUTION OF MYO-INOSITOL OXYGENASE IN AGE: RAGE MEDIATED RENAL TUBULO-INTERSTITIAL INJURY IN THE CONTEXT OF DIABETIC NEPHROPATHY
Sharma, Tupe, Wallner et al
Am. J. Physiol. Renal Physiol. (2017)
AI Summary: In this study, OriGene's MIOX-siRNA (SR310776) was used to specifically silence MIOX expression, enabling the authors to demonstrate the key role of MIOX in AGE:RAGE-mediated renal tubulo-interstitial injury associated with diabetic nephropathy.
Snippet: protein 157 (SRP6051), 2′,7′-dichlorofluorescin diacetate (DCF-DA, D6883), anti-actin (A5441) and - 158 fibronectin (F7387) antibody;OriGene technologies: MIOX-siRNA (SR310776);Calbiochem: 4- 159 Chloro-N-Cyclohexyl ...;... protein 157 (SRP6051), 2′,7′-dichlorofluorescin diacetate (DCF-DA, D6883), anti-actin (A5441) and - 158 fibronectin (F7387) antibody;Calbiochem: 4- 159 Chloro-N-Cyclohexyl
Showing 1-2 of 2 papers.
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