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Sm (Smith Antigen) Bovine Protein

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SKU
AR00133PU-N
Sm (Smith Antigen) bovine protein, 1 kU
Size:
1 kU
  $1,945.00
2 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Species Bovine
Protein Source Spleen
Concentration lot specific
Purity Immobilized human anti-Sm immune globulins. Purification is verified by SDS PAGE. Other antigens (SSA, SSB, RNP, Scl-70, Jo-1) are not detected with ELISA assays.
Presentation State Aff - Purified
Buffer Presentation State: Aff - Purified
State: Liquid purified
Buffer System: 0.01M Tris, 0.53M Sodium chloride containing 0.02% Sodium azide
Bioactivity Biological: One unit of activity is the amount of antigen that will generate an absorbance of 1.2 when assayed using standard procedure for enzyme immunoassay. Activity will vary with assay conditions/protocols.
Specific: 1000 Units/ml
Preparation Liquid purified
Recommended Dilution Use in standard solid phase immunoassays.
Protein Description Sm (Smith) Antigen
Storage Store the protein at -70°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Dry Ice
Reference Data
Synonyms Human Autoantigens
Summary The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE. This antibody recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. It precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.
Protein Families Use in standard solid phase immunoassays.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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