USP2 (NM_171997) Human Mass Spec Standard

SKU
PH317695
USP2 MS Standard C13 and N15-labeled recombinant protein (NP_741994)
  $3,360.00
3 Weeks*
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Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC217695
Predicted MW 45.1 kDa
Protein Sequence
Protein Sequence
>RC217695 representing NM_171997
Red=Cloning site Green=Tags(s)

MRTSYTVTLPEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMN
SILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR
FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQL
KSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKF
SIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYT
AYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_741994
RefSeq Size 1378
RefSeq ORF 1188
Synonyms UBP41; USP9
Locus ID 9099
UniProt ID O75604
Cytogenetics 11q23.3
Summary This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Aug 2011
Protein Families Protease
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Other "USP2" proteins (5)
SKU Description Size Price
LC401351 Lyophilized USP2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC403527 Lyophilized USP2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY401351 Transient overexpression lysate of ubiquitin specific peptidase 2 (USP2), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY403527 Transient overexpression lysate of ubiquitin specific peptidase 2 (USP2), transcript variant 2 (as WB positive control) 100 ug
$436.00
TP317695 Recombinant protein of human ubiquitin specific peptidase 2 (USP2), transcript variant 2, 20 µg 20 ug
$867.00

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