PPM1F (NM_014634) Human Mass Spec Standard
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC210043 |
| Predicted MW | 49.7 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_055449 |
| RefSeq Size | 5199 |
| RefSeq ORF | 1359 |
| Synonyms | CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2 |
| Locus ID | 9647 |
| UniProt ID | P49593 |
| Cytogenetics | 22q11.22 |
| Summary | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. provided by RefSeq, Jul 2008 |
| Protein Families | Druggable Genome, Phosphatase |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "PPM1F" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC402357 | Lyophilized PPM1F HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY402357 | Transient overexpression lysate of protein phosphatase 1F (PP2C domain containing) (PPM1F) (as WB positive control) | 100 ug |
$436.00
|
|
| TP310043 | Recombinant protein of human protein phosphatase 1F (PP2C domain containing) (PPM1F), 20 µg | 20 ug |
$867.00
|
|
Citations
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