SPSB1 (NM_025106) Human Mass Spec Standard

SKU
PH303673
SPSB1 MS Standard C13 and N15-labeled recombinant protein (NP_079382)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC203673
Predicted MW 30.9 kDa
Protein Sequence
Protein Sequence
>RC203673 protein sequence
Red=Cloning site Green=Tags(s)

MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKED
DKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESW
GWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLY
PVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_079382
RefSeq Size 3130
RefSeq ORF 819
Synonyms SSB-1; SSB1
Locus ID 80176
UniProt ID Q96BD6
Cytogenetics 1p36.22
Summary Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).UniProtKB/Swiss-Prot Function
Protein Families Druggable Genome
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Other "SPSB1" proteins (3)
SKU Description Size Price
LC410888 Lyophilized SPSB1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY410888 Transient overexpression lysate of splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1) (as WB positive control) 100 ug
$436.00
TP303673 Recombinant protein of human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1), 20 µg 20 ug
$867.00

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