RNF166 (NM_178841) Human Mass Spec Standard

SKU
PH303224
RNF166 MS Standard C13 and N15-labeled recombinant protein (NP_849163)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC203224
Predicted MW 26.1 kDa
Protein Sequence
Protein Sequence
>RC203224 protein sequence
Red=Cloning site Green=Tags(s)

MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCLQVPSPLCP
LCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANCPKFVPVVPTSQPI
PSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKF
SYDTFVDYSIDEEAAFQAALALSLSEN

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_849163
RefSeq Size 1888
RefSeq ORF 711
Locus ID 115992
UniProt ID Q96A37
Cytogenetics 16q24.2-q24.3
Summary E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).UniProtKB/Swiss-Prot Function
Protein Families Druggable Genome
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Other "RNF166" proteins (3)
SKU Description Size Price
LC405857 Lyophilized RNF166 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY405857 Transient overexpression lysate of ring finger protein 166 (RNF166), transcript variant 1 (as WB positive control) 100 ug
$436.00
TP303224 Recombinant protein of human ring finger protein 166 (RNF166), 20 µg 20 ug
$867.00

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