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FLT3 (NM_004119) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC211459L4V
Lenti ORF particles, FLT3 (mGFP-tagged) - Human fms-related tyrosine kinase 3 (FLT3), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
mGFP w/ Puro DDK mGFP DDK w/ Puro
  $1,913.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol FLT3
Synonyms CD135; FLK-2; FLK2; STK1
Vector pLenti-C-mGFP-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC211459).
ACCN NM_004119
ORF Size 2979 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_004119.1
RefSeq Size 3475 bp
RefSeq ORF 2982 bp
Locus ID 2322
UniProt ID P36888
Cytogenetics 13q12.2
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer
MW 112.7 kDa
Summary This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. provided by RefSeq, Jan 2015
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Documents
Resources

file-alt Citations

Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34+ Hematopoietic Progenitor Cells from Apoptosis
Hancock, Crawford, Perez et al
mSphere (2021) 6 (1) DOI: 10.1128/mSphere.00986-20
AI Summary: OriGene’s pLenti-FLT3-mGFP-P2A-Puro lentiviral construct (RC211459L4V) was used to generate THF cells stably expressing human FLT3 receptor, enabling the study of HCMV-mediated regulation of apoptosis in hematopoietic progenitor cells.
Snippet: and l-glutamine. Stably transduced THF expressing human Flt-3R were generated by transduction with the lentivirus pLenti-FLT3-mGFP-P2A-Puro (OriGene Technologies RC211459L4V) followed by GFP purification after 1 week of Puro (800 μg/ml) selection
FigureFigureFigure
Showing 1-1 of 1 papers.
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