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NADPH oxidase 4 (NOX4) (NM_016931) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC208007L4V
Lenti ORF particles, NOX4 (mGFP-tagged) - Human NADPH oxidase 4 (NOX4), transcript variant 1, 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
mGFP w/ Puro DDK mGFP DDK w/ Puro
  $1,088.00
2 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol NADPH oxidase 4
Synonyms KOX; KOX-1; RENOX
Vector pLenti-C-mGFP-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC208007).
ACCN NM_016931
ORF Size 1734 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_016931.2
RefSeq Size 4459 bp
RefSeq ORF 1737 bp
Locus ID 50507
UniProt ID Q9NPH5
Cytogenetics 11q14.3
Protein Families Druggable Genome, Transmembrane
MW 66.9 kDa
Summary This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.provided by RefSeq, Jan 2009
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Documents
Resources

file-alt Citations

Challenging the role of a NOX4-Piezo1 axis in neutrophil bactericidal function
Knaus, Clark, Nauseef et al
Immunity (2024) 57 (8), 1716-1718 DOI: 10.1016/j.immuni.2024.07.012
Cited by 4
AI Summary: OriGene’s NOX4-mGFP plasmid (RC208007L4V) was used in this study to overexpress inactive NOX4 in differentiated HL60 cells for investigating NOX4 localization and its potential role in neutrophil function.
Snippet: … The proposed phagolysosomal localization of NOX4 rests on overexpression of inactive NOX4 (NOX4-mGFP, OriGene RC208007L4V) in differentiated HL60 cells without co-localizing phagocytosed bacteria with NOX4 and NOX2, and without measuring phagosomal NOX4-derived H2O2 (Figures S6A and S6B1), both critical determinants to support any clai
trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing
Mukhopadhyay, Tsukasaki, Chan et al
Immunity (2023) 57 (1), 52-67.e10 DOI: 10.1016/j.immuni.2023.11.007
Cited by 95
AI Summary: OriGene’s Nox4-mGFP-tagged lentiviral particles (Cat# RC208007L4V) were used to generate HL-60 cells expressing Nox4-mGFP, enabling the study of NADPH oxidase 4’s role in neutrophil bactericidal function during trans-endothelial migration.
Snippet: HL-60 cells were transduced with Nox4-mGFP-tagged lentiviral particles (OriGene, #RC208007L4V) and expressing cells were selected with puromycin. The Nox4-mGFP expressing HL-60 were differentiated as described above, plated on a glass bottom dish coated with fibrinogen, and were allowed to adhere for 1h
Showing 1-2 of 2 papers.
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