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IL1 beta (IL1B) (NM_000576) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC202079L1V
Lenti ORF particles, IL1B (Myc-DDK tagged) - Human interleukin 1, beta (IL1B), 200ul, >10^7 TU/mL
  $1,000.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol IL1 beta
Synonyms IL-1; IL1-BETA; IL1beta; IL1F2
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC202079).
ACCN NM_000576
ORF Size 807 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_000576.2
RefSeq Size 1498 bp
RefSeq ORF 810 bp
Locus ID 3553
UniProt ID P01584
Cytogenetics 2q14.1
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus
MW 30.7 kDa
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. provided by RefSeq, Jul 2020
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Documents
Resources

file-alt Citations

The Homeoprotein DLX4 Stimulates NF-κB Activation and CD44-Mediated Tumor-Mesothelial Cell Interactions in Ovarian Cancer
Haria, Trinh, Ko et al
Am. J. Pathol. (2015)
Cited by 34
AI Summary: OriGene products, specifically the IL1B cDNA and pGFP-V-RS nontargeting and DLX4 shRNA plasmids, were used in this study to manipulate gene expression and investigate the roles of IL1B and DLX4 in ovarian cancer cell signaling and metastasis.
Snippet: Sources of other plasmids were as follows: IL1B cDNA and pGFP-V-RS nontargeting and DLX4 shRNA plasmids (OriGene Technologies, Rockville, MD);pGIPZ nontargeting and IL1B shRNA plasmids (MD Anderson Cancer Center shRNA and ORFeome Core Facility ... Cite SaveSaving
Showing 1-1 of 1 papers.
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