OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

LDL Receptor (LDLR) (NM_000527) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
  • Product Brand Image
Be the first to review this product
SKU
RC200006L1V
Lenti ORF particles, LDLR (Myc-DDK tagged) - Human low density lipoprotein receptor (LDLR), transcript variant 1, 200ul, >10^7 TU/mL
  $1,731.00
3 Weeks*
Bulk Requests & Clone Modifications

Frequently Bought Together (3)

TA812510 LDLR mouse monoclonal antibody,clone OTI7C5 100 ul
$447.00
TR30038 One-Wash Lentivirus Titer Kit, HIV-1 p24 ELISA
96 reactions
$700.00
PS100064V Lenti ORF control particles of pLenti-C-Myc-DDK, 10^7 TU/mL, 0.5 mL
500 ul
$380.00

Other products for "LDL Receptor or NM_000527"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol LDL Receptor
Synonyms FH; FHC; FHCL1; LDLCQ2
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC200006).
ACCN NM_000527
ORF Size 2580 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_000527.2, NP_000518.1
RefSeq Size 5175 bp
RefSeq ORF 2583 bp
Locus ID 3949
UniProt ID P01130
Cytogenetics 19p13.2
Domains EGF, EGF_CA, ldl_recept_a, ldl_recept_b
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Endocytosis
MW 95.38 kDa
Summary The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.provided by RefSeq, Sep 2010
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Release of VSVG-pseudotyped Lentivirus from the Host Cell is impaired upon Low-density Lipoprotein Receptor Overexpression
Otahal, Fuchs, Al-Allaf et al
J. Virol. (2015)
AI Summary: OriGene plasmids encoding LDLR (#RC200006), ICAM1 (#RC200714), and TfR1 (#RC200980) were used to overexpress these proteins in HEK293 cells, enabling the study of their effects on VSVG-pseudotyped lentivirus production and release.
Snippet: Cells were then cotransfected with different 46 amounts of plasmids encoding either LDLR (Origene #RC200006) or, as controls, human 47 intercellular adhesion molecule 1 (ICAM1;Origene #RC200714) and human transferrin receptor 48 (TfR1;Origene #RC200980 ... Cite SaveSaving
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products