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EFS (NM_032459) Human Untagged Clone

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SKU
SC323937
EFS (untagged)-Human embryonal Fyn-associated substrate (EFS), transcript variant 2
  $457.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol EFS
Synonyms CAS3; CASS3; EFS1; EFS2; HEFS; SIN
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_032459.1 GTGGGTTTTCTTTCTCCTCCTCCAACCTTGGCGGAGGCCACGACTCAGGCGCCACAGCTG
GGGGCTAGAGGCCGCGGACCATGGTGCGGGGCAGCCACCGCTGAAGTCAGCAAAACCGAG
CCTGGCCTGAGGCAGGCTGCGCGGGAGGCCAAAGCCATGGCCATTGCCACGTCGGTGTAT
GTGGTGCCGCCCCCAGCTCGGCCCTGTCCAACCTCAGGACCTCCAGCTGGACCTTGCCCA
CCCTCTCCTGACCTCATCTACAAAATCCCCAGAGCTAGTGGGACCCAGCTGGCTGCTCCC
AGAGATGCCTTGGAGGTCTACGATGTGCCCCCCACCGCCCTCCGGGTGCCCTCCAGTGGC
CCCTATGACTGCCCTGCCTCCTTTTCCCACCCTCTGACCCGGGTTGCCCCGCAGCCCCCT
GGAGAGGATGATGCTCCCTATGATGTGCCTCTGACCCCAAAGCCACCTGCAGAGCTGGAA
CCAGATCTGGAGTGGGAAGGAGGCCGGGAGCCGGGGCCCCCCATCTATGCTGCCCCCTCC
AACCTGAAACGAGCGTCAGCCTTACTCAATTTGTATGAAGCACCCGAGGAACTGCTGGCA
GACGGGGAGGGCGGGGGCACTGATGAGGGGATCTACGATGTGCCTCTGCTGGGGCCAGAG
GCTCCCCCTTCTCCAGAGCCCCCTGGAGCCTTGGCCTCCCATGACCAGGACACCCTGGCC
CAGCTTCTGGCCAGAAGCCCCCCACCCCCACACAGGCCCCGGCTCCCCTCAGCTGAGAGC
CTGTCCCGCCGCCCTCTGCCTGCCCTGCCTGTCCCTGAGGCCCCCAGCCCCTCCCCAGTG
CCCTCTCCTGCCCCAGGCCGGAAGGGCAGCATCCAGGACCGGCCTCTGCCCCCACCCCCA
CCCCGCCTGCCTGGTTATGGAGGCCCCAAGGTCGAGGGGGATCCAGAGGGCAGGGAGATG
GAGGATGACCCAGCAGGACACCACAATGAGTACGAGGGCATTCCGATGGCCGAGGAGTAT
GACTATGTCCACCTGAAGGGCATGGACAAAGCTCAGGGATCTAGGCCCCCGGATCAGGCC
TGCACAGGGGATCCTGAACTGCCCGAGAGGGGGATGCCGGCGCCGCAGGAGGCCCTGTCC
CCAGGGGAGCCACTGGTTGTGTCCACCGGAGATCTGCAGCTCCTGTACTTCTATGCTGGG
CAATGCCAGAGCCACTACTCAGCCCTGCAGGCAGCCGTGGCAGCCCTGATGTCCAGTACC
CAGGCTAATCAGCCCCCGCGCCTTTTCGTGCCCCACAGCAAGAGGGTGGTGGTGGCTGCT
CATCGCCTGGTGTTTGTTGGGGACACCCTGGGCCGGCTGGCAGCCTCTGCCCCTCTGAGA
GCACAGGTCAGGGCTGCAGGTACAGCACTGGGCCAGGCATTGCGGGCCACTGTGCTGGCT
GTCAAGGGAGCTGCCCTGGGCTACCCATCCAGCCCTGCCATCCAAGAGATGGTGCAGTGT
GTAACAGAACTGGCAGGGCAGGCCCTGCAATTCACTACCCTGCTCACTAGCCTGGCTCCA
TGAAGGTCCTTTGGCACAGCTCTGCTCCTCCCCTGCCTGCCAAAGCCCCCCTTTAGGCCT
TGGGTGGCTGGAAGGCTTTGTTAAGGGACTAGGAGAAATGGGGGTATCTTTCCCCTTTCC
TGCCCTTTCTGCTCATCTCAACCTCTCACAGAGGTGTCTTCTCCCCCTAACCTACAGCTT
TTTGTACAAGCCATTTTGTGTAAATTATTTATATTTAATATTATTCCCTGCTTTGTCAGG
AGCAGGTACTAGGCTCTGGGGCAGTGAGGAACTAGATCCTTCTCTCCTCAGCCTAGGGTG
GAGGTCACTGCACTACCACCCACCTCTGGAAGACTGGCTGTGAAAAGTCAGGTGGCAGAA
ACCTGGGGCCACATAGAGCCTCTCTCTTTTCCTGTTTCTTGGCTCTAGAAGATCAGCACT
GCACTGTTAGCTGAGAGTGCGGGCAAGACATAAACTGTCCAGAGTTTGAAGGTTCTCGGA
AAGACCGGAGGGCTTCTCCCCACAGAAGGCGGAGAGAGCTGGGGCTCAGACATGGGTGTG
CACCTTAATAAACCCTGCTGTCTGCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites ECoRI-NOT |
ACCN NM_032459
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_032459.1, NP_115835.1
RefSeq Size 2853 bp
RefSeq ORF 1407 bp
Locus ID 10278
UniProt ID O43281
Cytogenetics 14q11.2
Summary The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin binding leads to the subsequent phosphorylation of a CAS protein. Additional binding of SRC family kinases leads to CAS hyperphosphorylation and the creation of binding sites for CRK and other proteins that cause actin cytoskeleton reorganization. This gene plays a role in integrin-mediated cell attachment, spreading, and migration and also plays a role in both normal and malignant cellular transformation. This broadly expressed gene has been shown to play a role in neurite outgrowth and its expression in the thymus and lymphocytes is important for T cell maturation and the development of immunological self-tolerance. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Jul 2020
Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. This isoform lacks the N-terminal SH3 domain found in isoform 1.
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Documents
Resources
"NM_032459" in other vectors (5)
SKU Description Size Price
RC203800 EFS (Myc-DDK-tagged)-Human embryonal Fyn-associated substrate (EFS), transcript variant 2 10 ug
$457.00
RC203800L3 Lenti ORF clone of Human embryonal Fyn-associated substrate (EFS), transcript variant 2, Myc-DDK-tagged 10 ug
$757.00
RC203800L4 Lenti ORF clone of Human embryonal Fyn-associated substrate (EFS), transcript variant 2, mGFP tagged 10 ug
$757.00
RG203800 EFS (tGFP-tagged) - Human embryonal Fyn-associated substrate (EFS), transcript variant 2 10 ug
$489.00 $657.00
SC110138 EFS (untagged)-Human embryonal Fyn-associated substrate (EFS), transcript variant 2 10 ug
$457.00

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