ELAVL1 (NM_001419) Human Untagged Clone
SKU
SC322158
ELAVL1 (untagged)-Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1)
$300.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | ELAVL1 |
| Synonyms | ELAV1; Hua; HUR; MelG |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_001419 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001419.2, NP_001410.2 |
| RefSeq Size | 6075 bp |
| RefSeq ORF | 981 bp |
| Locus ID | 1994 |
| UniProt ID | Q15717 |
| Cytogenetics | 19p13.2 |
| Domains | RRM |
| Summary | The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. provided by RefSeq, Sep 2012 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001419" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201562 | ELAVL1 (Myc-DDK-tagged)-Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1) | 10 ug |
$289.00
$300.00
|
|
| RC201562L1 | Lenti ORF clone of Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1), Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC201562L2 | Lenti ORF clone of Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1), mGFP tagged | 10 ug |
$600.00
|
|
| RC201562L3 | Lenti ORF clone of Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1), Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC201562L4 | Lenti ORF clone of Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1), mGFP tagged | 10 ug |
$600.00
|
|
| RG201562 | ELAVL1 (tGFP-tagged) - Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1) | 10 ug |
$489.00
$500.00
|
|
| SC119271 | ELAVL1 (untagged)-Human ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1) | 10 ug |
$300.00
|
|
Citations
Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent
Chu, Kulp, Chen
Carcinogenesis (2013)
Chu, Kulp, Chen
Carcinogenesis (2013)
Cited by 7
AI Summary: OriGene products contributed to this study by providing the full-length Sp1 and HuR human cDNA clones, which were used to investigate the roles of these proteins in regulating IGF-IR expression and mRNA stability in prostate cancer cells.
Snippet: The full-length Sp1 and HuR human complementary DNA (cDNA) clones were purchased from OriGene Technologies (Rockville, MD) and subcloned into the ... inhibition of transcription by the RNA synthesis inhibitor actinomycin D. Treatment with CG-5 shortened the half-life (t 1
Interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability
England, Preston, Scalia et al
Am. J. Physiol., Cell Physiol. (2013) 305 (3), C255-65 DOI: 10.1152/ajpcell.00069.2013
England, Preston, Scalia et al
Am. J. Physiol., Cell Physiol. (2013) 305 (3), C255-65 DOI: 10.1152/ajpcell.00069.2013
Cited by 35
AI Summary: OriGene's HuR cDNA expression vector was used in this study to overexpress HuR in endothelial cells, enabling the investigation of HuR's role in regulating mRNA stability of adhesion molecules affected by interleukin-19.
Snippet: RNA was extracted 72 hours post-transfection. HuR cDNA was purchased in an 141 expression vector (Origene Technologies) and was over expressed by transfection of 142 2μg/106 ECs using the NucleofectorTM kit as described for siRNA. 143 144
Showing 1-2 of 2 papers.
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