HDAC8 (NM_018486) Human Untagged Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | HDAC8 |
| Synonyms | CDA07; CDLS5; HD8; HDACL1; KDAC8; MRXS6; RPD3; WTS |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_018486 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_018486.1, NP_060956.1 |
| RefSeq Size | 1743 bp |
| RefSeq ORF | 1134 bp |
| Locus ID | 55869 |
| UniProt ID | Q9BY41 |
| Cytogenetics | Xq13.1 |
| Domains | Hist_deacetyl |
| Protein Families | Druggable Genome, Transcription Factors |
| Summary | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2009 Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: A downstream translational start codon is selected for this RefSeq based on a strong Kozak signal and transcript support. An upstream in-frame start codon is also present but has a weaker Kozak signal and sparse transcript support. Use of the upstream start codon would result in a protein that is 38 aa longer at the N-terminus. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon, which is supported by 5'RACE experiments described in PubMed: 10922473 and encodes a protein with an N-terminus similar to other family members. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_018486" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC208390 | HDAC8 (Myc-DDK-tagged)-Human histone deacetylase 8 (HDAC8), transcript variant 1 | 10 ug |
$457.00
|
|
| RC208390L1 | Lenti ORF clone of Human histone deacetylase 8 (HDAC8), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC208390L2 | Lenti ORF clone of Human histone deacetylase 8 (HDAC8), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RC208390L3 | Lenti ORF clone of Human histone deacetylase 8 (HDAC8), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC208390L4 | Lenti ORF clone of Human histone deacetylase 8 (HDAC8), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RG208390 | HDAC8 (tGFP-tagged) - Human histone deacetylase 8 (HDAC8), transcript variant 1 | 10 ug |
$489.00
$657.00
|
|
Citations
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells
Kang, Nian, Rajendran et al
Cell Death Dis (2014) 5, e1476 DOI: 10.1038/cddis.2014.422
Kang, Nian, Rajendran et al
Cell Death Dis (2014) 5, e1476 DOI: 10.1038/cddis.2014.422
Cited by 84
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
Duncan, An, Papanikolaou et al
Mol Neurodegener (2013) 8, 42 DOI: 10.1186/1750-1326-8-42
Duncan, An, Papanikolaou et al
Mol Neurodegener (2013) 8, 42 DOI: 10.1186/1750-1326-8-42
Cited by 26
AI Summary: OriGene products, specifically the human ataxin-7 Myc-DDK-tagged cDNA clone, were used to express ataxin-7 in cell studies, enabling the researchers to investigate the interaction and posttranslational modification effects of HDAC3 on ataxin-7 in the context of spinocerebellar ataxia type 7.
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
