DAB2 (NM_001343) Human Untagged Clone
SKU
SC321375
DAB2 (untagged)-Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2)
$706.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | DAB2 |
| Synonyms | DOC-2; DOC2 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_001343 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001343.1, NP_001334.1 |
| RefSeq Size | 3268 bp |
| RefSeq ORF | 2313 bp |
| Locus ID | 1601 |
| UniProt ID | P98082 |
| Cytogenetics | 5p13.1 |
| Domains | PID |
| Protein Families | Druggable Genome |
| Protein Pathways | Endocytosis |
| Summary | This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2011 Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001343" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC200481 | DAB2 (Myc-DDK-tagged)-Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2) | 10 ug |
$705.00
|
|
| RC200481L1 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), Myc-DDK-tagged | 10 ug |
$1,005.00
|
|
| RC200481L2 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), mGFP tagged | 10 ug |
$1,005.00
|
|
| RC200481L3 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), Myc-DDK-tagged | 10 ug |
$1,005.00
|
|
| RC200481L4 | Lenti ORF clone of Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), mGFP tagged | 10 ug |
$1,005.00
|
|
| RG200481 | DAB2 (tGFP-tagged) - Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2) | 10 ug |
$789.00
$905.00
|
|
Citations
The histone demethylase Kdm3a is essential to progression through differentiation
Herzog, Josseaux, Dedeurwaerder et al
Nucleic Acids Res. (2012) 40 (15), 7219-32 DOI: 10.1093/nar/gks399
Herzog, Josseaux, Dedeurwaerder et al
Nucleic Acids Res. (2012) 40 (15), 7219-32 DOI: 10.1093/nar/gks399
Cited by 33
AI Summary: OriGene's Dab2 cDNA clone (MC200502) was used to generate expression constructs for functional studies investigating the role of Dab2 in cell differentiation in this paper.
Snippet: Dab2 cDNA was subcloned from a commercially available clone (Origene, MC200502) into pcDNA3.1-HA (CMV promoter ... from independent differentiation experiments for gene expression, the very high reproducibility of the microarray data further suggests good robustness for
Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells
Cihil, Ellinger, Fellows et al
J Biol Chem (2012) 287 (18), 15087-99 DOI: 10.1074/jbc.M112.341875
Cihil, Ellinger, Fellows et al
J Biol Chem (2012) 287 (18), 15087-99 DOI: 10.1074/jbc.M112.341875
AI Summary: In this study, OriGene's CFTR (SC300515) and DAB2 (SR304378) shRNA products were used to specifically knock down the expression of CFTR and Disabled-2 proteins, enabling the authors to investigate their roles in endocytosis and vesicle recruitment in human airway epithelial cells.
Showing 1-2 of 2 papers.
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